GSK-3α polyclonal, anti-human antibody
€295.00
In stock
SKU
AC-ABV11227-100
Catalog Number: AC-ABV11227-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Glycogen synthase kinase 3-alpha is a multifunctional protein serine kinase. GSK-3 phosphorylates and inactivates glycogen synthase. It has also been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate Cyclin D1 proteolysis and subcellular localization. GSK-3alpha (GSK-3α) regulates the production of amyloid-beta peptides, a major component of the plaques that accumulate with progression of Alzheimer's disease, by phosphorylating Tau proteins. This presents the possibility that defects in GSK-3 signaling can contribute to the onset of Alzheimer’s disease. GSK-3α can be phosphorylated by Akt at Ser21. This phosphorylation of GSK-3α negatively regulates its kinase activity.
Other Names:
Serine/threonine-protein kinase GSK3A, GSK-3alpha, Glycogen synthase kinase-3, GSK-3 alpha
Primary Accession: P49840
Other Accession: NP_063937
Gene Name: GSK3A
Gene ID: 2931
Concentration (mg/ml): 0.5 mg/ml
Glycogen synthase kinase 3-alpha is a multifunctional protein serine kinase. GSK-3 phosphorylates and inactivates glycogen synthase. It has also been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate Cyclin D1 proteolysis and subcellular localization. GSK-3alpha (GSK-3α) regulates the production of amyloid-beta peptides, a major component of the plaques that accumulate with progression of Alzheimer's disease, by phosphorylating Tau proteins. This presents the possibility that defects in GSK-3 signaling can contribute to the onset of Alzheimer’s disease. GSK-3α can be phosphorylated by Akt at Ser21. This phosphorylation of GSK-3α negatively regulates its kinase activity.
Other Names:
Serine/threonine-protein kinase GSK3A, GSK-3alpha, Glycogen synthase kinase-3, GSK-3 alpha
Primary Accession: P49840
Other Accession: NP_063937
Gene Name: GSK3A
Gene ID: 2931
Concentration (mg/ml): 0.5 mg/ml
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