GSK3β (clone 1A6), anti-human, mouse, rat

Background:
In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA.

Synonyms: GSK3β

Cellular Location: Cell membrane Cytoplasm Nucleus

Immunogen:
Synthetic Peptide

Gene Symbol: GSK3β

Gene ID: 2932

Swiss prot: P49841

Calculated MW: 46kDa

Recommended dilution:
WB 1:1000-2000, IHC 1:100-200

Purity:
Saturated ammonium sulfate precipitation

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.