GSTA1 antibody (clone 2F7), anti-human
€435.00
In stock
SKU
AC-AT2275a
Catalog Number: AC-AT2275a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, E
Request Information AC-AT2275a">Request Information
Background:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
Other Names:
Glutathione S-transferase A1, GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, N-terminally processed, GSTA1
Antigen Type:
Recombinant Protein
Gene Name: GSTA1
Gene ID: 2938
NCBI Accession: NP_665683.1
Primary Accession: P08263
Other Accession: BC053578.1
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
Other Names:
Glutathione S-transferase A1, GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, N-terminally processed, GSTA1
Antigen Type:
Recombinant Protein
Gene Name: GSTA1
Gene ID: 2938
NCBI Accession: NP_665683.1
Primary Accession: P08263
Other Accession: BC053578.1
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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