GSTA3 antibody (clone 1F11), anti-human
€435.00
In stock
SKU
AC-AT2277a
Catalog Number: AC-AT2277a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, E
Request Information AC-AT2277a">Request Information
Background:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.
Other Names:
Glutathione S-transferase A3, GST class-alpha member 3, Glutathione S-transferase A3-3, GSTA3
Antigen Type:
Recombinant Protein
Gene Name: GSTA3 (HGNC:4628)
Gene ID: 2940
NCBI Accession: NP_000838.3
Primary Accession: Q16772
Other Accession: BC020619
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.
Other Names:
Glutathione S-transferase A3, GST class-alpha member 3, Glutathione S-transferase A3-3, GSTA3
Antigen Type:
Recombinant Protein
Gene Name: GSTA3 (HGNC:4628)
Gene ID: 2940
NCBI Accession: NP_000838.3
Primary Accession: Q16772
Other Accession: BC020619
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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