GSTM1 Polyclonal Antibody

Background:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

Research Area: Tags & Cell Markers,Signal Transduction,Metabolism

Synonyms:
GST class-mu 1, GST HB subunit 4, GST1, Gstm1, GSTM1a-1a, GTH4, GTM1, H-B, MU

Immunogen: Recombinant Mouse Glutathione S-transferase Mu 1 protein

Swissprot: P10649

Calculated MW: 26 kDa
Observed MW: 26 kDa

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 0.54 mg/mL
Dilution: WB 1:500-1:6000 IHC 1:100-1:200 IF 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.