GSTM2 Polyclonal Antibody

Background:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

Research Area: Signal Transduction, Metabolism

Synonyms:
Glutathione S alkyltransferase M2, Glutathione S transferase 4, Glutathione S transferase M1, GST class mu 2, GST muscle, GST4, GSTM, GSTM2, GTHMUS

Immunogen: Recombinant Rat Glutathione S-transferase Mu 2 protein

Swissprot: P08010
Gene ID: 24424

Calculated MW: 25 kDa
Observed MW: 25 kDa

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3

Concentration: 0.14 mg/mL
Dilution: WB 1:500-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.