GSTM4 antibody (clone 4B4), anti-human
€435.00
In stock
SKU
AC-AT2279a
Catalog Number: AC-AT2279a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
Request Information AC-AT2279a">Request Information
Background:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
Other Names:
Glutathione S-transferase Mu 4, GST class-mu 4, GST-Mu2, GSTM4-4, GSTM4
Antigen Type:
Recombinant Protein
Gene Name: GSTM4
Gene ID: 2948
NCBI Accession: NP_000841.1;NP_671489.1
Primary Accession: Q03013
Other Accession: BC015513
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
Other Names:
Glutathione S-transferase Mu 4, GST class-mu 4, GST-Mu2, GSTM4-4, GSTM4
Antigen Type:
Recombinant Protein
Gene Name: GSTM4
Gene ID: 2948
NCBI Accession: NP_000841.1;NP_671489.1
Primary Accession: Q03013
Other Accession: BC015513
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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