N33 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP71144
Background:
Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.
Other Names:
TUSC3; N33; Tumor suppressor candidate 3; Magnesium uptake/transporter TUSC3; Protein N33
Antigen Type: synthetic peptide
Antigen Type: TUSC3
Gene ID: 7991
Primary Accession: Q13454
Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.
Other Names:
TUSC3; N33; Tumor suppressor candidate 3; Magnesium uptake/transporter TUSC3; Protein N33
Antigen Type: synthetic peptide
Antigen Type: TUSC3
Gene ID: 7991
Primary Accession: Q13454
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