GTF3A Polyclonal Antibody

Background:
The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
AP 2, AP2, Factor A, General transcription factor 3A, General transcription factor IIIA, GTF 3A, GTF3A, TF3A, TFIIIA, Transcription factor 3A, Transcription factor IIIA

Immunogen: Synthetic peptide of human GTF3A

Swissprot: Q92664
Gene Accession: NP002088

Calculated MW: 42 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.68 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.