GTPBP5 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61198
Background:
Small G proteins act as molecular switches for regulation of variety of cellular processes, such as nuclear transport, signal transduction, membrane trafficking and protein synthesis. GTPBP5 (GTP-binding protein 5), also known as OBGH1, is a 406 amino acid small G protein that contains an amino-terminal mitochondria-localization signal. Knockdown of GTPBP5 mRNA results in abnormal nuclear morphologies and elongated mitochondria. In vitro studies demonstrate that GTPBP5 exhibits GTPase activity, cycling between an active GTP-bound state and an inactive GDP-bound state. Activation of GTPases usually results in rearrangements of filamentous actin and the formation of actin stress fibers.
Alternative Name:
Mitochondrial ribosome-associated GTPase 2, GTP-binding protein 5, Protein obg homolog 1, ObgH1, MTG2, GTPBP5, OBGH1
Application Dilution: WB: 1:500~1:1000
Specificity: GTPBP5 polyclonal antibody detects endogenous levels of GTPBP5 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human GTPBP5.
MW: ~ 44 kDa
Swis Prot.: Q9H4K7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Small G proteins act as molecular switches for regulation of variety of cellular processes, such as nuclear transport, signal transduction, membrane trafficking and protein synthesis. GTPBP5 (GTP-binding protein 5), also known as OBGH1, is a 406 amino acid small G protein that contains an amino-terminal mitochondria-localization signal. Knockdown of GTPBP5 mRNA results in abnormal nuclear morphologies and elongated mitochondria. In vitro studies demonstrate that GTPBP5 exhibits GTPase activity, cycling between an active GTP-bound state and an inactive GDP-bound state. Activation of GTPases usually results in rearrangements of filamentous actin and the formation of actin stress fibers.
Alternative Name:
Mitochondrial ribosome-associated GTPase 2, GTP-binding protein 5, Protein obg homolog 1, ObgH1, MTG2, GTPBP5, OBGH1
Application Dilution: WB: 1:500~1:1000
Specificity: GTPBP5 polyclonal antibody detects endogenous levels of GTPBP5 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human GTPBP5.
MW: ~ 44 kDa
Swis Prot.: Q9H4K7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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