GUCY2C Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7136b
Background:
Guanylyl cyclase C (GUCY2C) is a transmembrane receptor expressed primarily in the intestine that regulates chloride secretion via the cystic fibrosis transmembrane conductance regulator. Binding of GUCY2C to either the endogenous peptide guanylin or the bacterially derived heat-stable enterotoxin STa, results in increased levels of cGMP and the stimulation of water and chloride secretion. In the case of exposure to STa, this leads to debilitating secretory diarrhea.
Other Names:
Heat-stable enterotoxin receptor, STA receptor, hSTAR, Guanylyl cyclase C, GC-C, Intestinal guanylate cyclase, GUCY2C, GUC2C, STAR
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7136b was selected from the C-term region of human GUCY2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GUCY2C {ECO:0000303|PubMed:22521417, ECO:0000312|HGNC:HGNC:4688}
Gene ID: 2984
Primary Accession: P25092
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Guanylyl cyclase C (GUCY2C) is a transmembrane receptor expressed primarily in the intestine that regulates chloride secretion via the cystic fibrosis transmembrane conductance regulator. Binding of GUCY2C to either the endogenous peptide guanylin or the bacterially derived heat-stable enterotoxin STa, results in increased levels of cGMP and the stimulation of water and chloride secretion. In the case of exposure to STa, this leads to debilitating secretory diarrhea.
Other Names:
Heat-stable enterotoxin receptor, STA receptor, hSTAR, Guanylyl cyclase C, GC-C, Intestinal guanylate cyclase, GUCY2C, GUC2C, STAR
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7136b was selected from the C-term region of human GUCY2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GUCY2C {ECO:0000303|PubMed:22521417, ECO:0000312|HGNC:HGNC:4688}
Gene ID: 2984
Primary Accession: P25092
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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