GUCY2C Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP7136a
Background:
Guanylyl cyclase C (GC-C) is a transmembrane receptor expressed primarily in the intestine that regulates chloride secretion via the cystic fibrosis transmembrane conductance regulator. Binding of GC-C to either the endogenous peptide guanylin or the bacterially derived heat-stable enterotoxin STa, results in increased levels of cGMP and the stimulation of water and chloride secretion. In the case of exposure to STa, this leads to debilitating secretory diarrhea. GUCY2C is a receptor for STa, and is also activated by the endogenous peptide guanylin. The GUCY2C receptor has an extracellular ligand-binding domain and a cytoplasmic guanylyl cyclase domain, as do members of the natriuretic peptide receptor family.
Other Names:
Heat-stable enterotoxin receptor, STA receptor, hSTAR, Guanylyl cyclase C, GC-C, Intestinal guanylate cyclase, GUCY2C, GUC2C, STAR
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7136a was selected from the Center region of human GUCY2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GUCY2C {ECO:0000303|PubMed:22521417, ECO:0000312|HGNC:HGNC:4688}
Gene ID: 2984
Primary Accession: P25092
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Guanylyl cyclase C (GC-C) is a transmembrane receptor expressed primarily in the intestine that regulates chloride secretion via the cystic fibrosis transmembrane conductance regulator. Binding of GC-C to either the endogenous peptide guanylin or the bacterially derived heat-stable enterotoxin STa, results in increased levels of cGMP and the stimulation of water and chloride secretion. In the case of exposure to STa, this leads to debilitating secretory diarrhea. GUCY2C is a receptor for STa, and is also activated by the endogenous peptide guanylin. The GUCY2C receptor has an extracellular ligand-binding domain and a cytoplasmic guanylyl cyclase domain, as do members of the natriuretic peptide receptor family.
Other Names:
Heat-stable enterotoxin receptor, STA receptor, hSTAR, Guanylyl cyclase C, GC-C, Intestinal guanylate cyclase, GUCY2C, GUC2C, STAR
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7136a was selected from the Center region of human GUCY2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GUCY2C {ECO:0000303|PubMed:22521417, ECO:0000312|HGNC:HGNC:4688}
Gene ID: 2984
Primary Accession: P25092
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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