GW182 polyclonal, anti-human, mouse, rat
€469.00
In stock
SKU
252026
Protein Family: Translation Factors
Pathway and Disease: Translation
Description:
Trinucleotide repeat-containing gene 6A protein (GW182) plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). GW182 is required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. Antibodies against GW182 are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
Alternate Names: Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, Glycine-tryptophan protein of 182 kDa, GW182 autoantigen, Protein GW1, EMSY interactor protein, TNRC6A, CAGH26, KIAA1460, TNRC6
Application Notes: E: 1:1,000-1:10,000; WB: 1:100-1:500
Accession No.: Q8NDV7
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GW182.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Translation
Description:
Trinucleotide repeat-containing gene 6A protein (GW182) plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). GW182 is required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. Antibodies against GW182 are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
Alternate Names: Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, Glycine-tryptophan protein of 182 kDa, GW182 autoantigen, Protein GW1, EMSY interactor protein, TNRC6A, CAGH26, KIAA1460, TNRC6
Application Notes: E: 1:1,000-1:10,000; WB: 1:100-1:500
Accession No.: Q8NDV7
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GW182.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
| Is Featured? | No |
|---|
Write Your Own Review