H-Cadherin polyclonal, anti-human, mouse, rat

Background:
Cadherins comprise a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogen-esis. Cadherins each contain a large extracellular domains characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin), also designated heart-cadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cell lines. Evidence suggests that decreased levels of T-cadherin indicate a progression in breast malignancies.

Alternative Name:
H-cadherin, T-cad, T-cadherin, CDH13, CDHH, CAD13, Cadherin-13, CDH13, CDHH, H-cadherin, Heart cadherin, P105, T cad, T Cadherin, T-cad, T-cadherin, Truncated cadherin,

Application Dilution:
IHC:1:50-1:200
WB:1:50-1:200

Specificity: H-Cadherin polyclonal antibody detects endogenous levels of H-Cadherin protein.

Immunogen:
Recombinant protein within human H Cadherin aa 1-200.

MW: 78 kDa

Swiss-Prot: P55290(Human) Q9WTR5(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.