H2A.XS139p polyclonal, anti-human
€320.00
In stock
SKU
AC-ADN10135
Catalog Number: AC-ADN10135
Size: 50 µg
Host: Rabbit
Applications: WB, E, DB
Datasheet
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Size: 50 µg
Host: Rabbit
Applications: WB, E, DB
Datasheet
Request Information
Bio Background:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
Other Names:
Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX
Primary Accession: P16104
Gene ID: 3014
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
Other Names:
Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX
Primary Accession: P16104
Gene ID: 3014
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