H2AFX monoclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AM2199b
Catalog Number: AC-AM2199b
Size: 50 µl, 200 µl
Isotype: mouse IgG1
Clone Name: 938CT5.1.1
Applications: IHC-P, WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: mouse IgG1
Clone Name: 938CT5.1.1
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Other Names:
Histone H2AX, H2a/x, Histone H2AX, H2AFX, H2AX
Target/Specificity:
This H2AFX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the C-terminal region of human H2AFX.
Antigen Region:
115-143
Antigen Type: Synthetic Peptide
Gene Name: H2AX (HGNC:4739)
Gene ID: 3014
Primary Accession: P16104
NCBI Accession: NP_002096.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Other Names:
Histone H2AX, H2a/x, Histone H2AX, H2AFX, H2AX
Target/Specificity:
This H2AFX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the C-terminal region of human H2AFX.
Antigen Region:
115-143
Antigen Type: Synthetic Peptide
Gene Name: H2AX (HGNC:4739)
Gene ID: 3014
Primary Accession: P16104
NCBI Accession: NP_002096.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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