H2AFY2 Blocking Peptide (Center)

Background:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Other Names:
Core histone macro-H2A2, Histone macroH2A2, mH2A2, H2AFY2, MACROH2A2

Target/Specificity:
The synthetic peptide sequence is selected from aa 158-169 of Human H2AFY2

Gene Name: MACROH2A2 (HGNC:14453)

Gene ID: 55506
Primary Accession: Q9P0M6
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.