HABP2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8583
Background:
The hyaluronan-binding protein 2 (HABP2), also designated plasma hyaluronan-binding protein (PHBP) or factor VII-activating protease, belongs to the peptidase S1 family and contains three EGF-like domains, one kringle domain and one peptidase S1 domain. HABP2 is a heterodimer that contains a heavy chain of 50 kDa and a light chain of 27 kDa, which are linked by a disulfide bond. HABP2 is ubiquitously expressed and acts as a serine protease with fibrinogen and fibronectin being the major substrates. HABP2 has been shown to cleave the alpha-chain at multiple sites and the beta-chain between lysine53 and lysine54, but not the gamma-chain of fibrinogen. Overexpression of HABP2 has been shown to occur in lung adenocarcinomas and may be a useful biomarker for that type of cancer.
Alternative Name:
Hyaluronan-binding protein 2, Factor VII-activating protease, Factor seven-activating protease, FSAP, Hepatocyte growth factor activator-like protein, Plasma hyaluronan-binding protein, HABP2, HGFAL, PHBP
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: HABP2 polyclonal antibody detects endogenous levels of HABP2 protein.
Immunogen:
Recombinant full length Human HABP2.
MW: ~ 62kDa
Swis Prot.: Q14520
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The hyaluronan-binding protein 2 (HABP2), also designated plasma hyaluronan-binding protein (PHBP) or factor VII-activating protease, belongs to the peptidase S1 family and contains three EGF-like domains, one kringle domain and one peptidase S1 domain. HABP2 is a heterodimer that contains a heavy chain of 50 kDa and a light chain of 27 kDa, which are linked by a disulfide bond. HABP2 is ubiquitously expressed and acts as a serine protease with fibrinogen and fibronectin being the major substrates. HABP2 has been shown to cleave the alpha-chain at multiple sites and the beta-chain between lysine53 and lysine54, but not the gamma-chain of fibrinogen. Overexpression of HABP2 has been shown to occur in lung adenocarcinomas and may be a useful biomarker for that type of cancer.
Alternative Name:
Hyaluronan-binding protein 2, Factor VII-activating protease, Factor seven-activating protease, FSAP, Hepatocyte growth factor activator-like protein, Plasma hyaluronan-binding protein, HABP2, HGFAL, PHBP
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: HABP2 polyclonal antibody detects endogenous levels of HABP2 protein.
Immunogen:
Recombinant full length Human HABP2.
MW: ~ 62kDa
Swis Prot.: Q14520
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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