HACE1 Polyclonal Antibody

Background:
HACE1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1), also known as KIAA1320, is a 909 amino acid protein that localizes to both the cytoplasm and the endoplasmic reticulum and contains one HECT domain and six ANK repeats. Expressed in kidney, heart and brain, HACE1 functions as an E3 ubiquitin-protein ligase that interacts with the proteasome and is thought to play a role in protein degradation. HACE1 is downregulated in Wilms tumor, suggesting a possible role in tumor suppression.

Research Area: Cancer, Cell biology, Epigenetics and Nuclear Signaling

Synonyms:
E3 ubiquitin-protein ligase HACE1, HACE 1, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, KIAA1320

Immunogen: Synthetic peptide of human HACE1

Swissprot: Q8IYU2
Gene Accession: NP_065822

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1.5 mg/mL
Dilution: IHC 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-139143