HAMP Polyclonal Antibody

Background:
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

Research Area: Cancer, Cardiovascular, Metabolism, Signaling transduction

Synonyms:
HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin

Immunogen: Recombinant fusion protein of human HAMP (NP_066998.1).

Swissprot: P81172
Gene ID: 57817

Calculated MW: 9 kDa
Observed MW: 10 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.