HAS1 Polyclonal Antibody

Background:
Hyaluronan or hyaluronic acid (HA) is a higHuman, Mouseolecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis.

Research Area: Cardiovascular, Developmental Biology, Neuroscience, Signal Transduction

Synonyms:
HA synthase 1, HAS, HAS1, HuHAS1, Hyaluronan synthase 1, Hyaluronate synthase 1, Hyaluronic acid synthase 1, HYAS1

Immunogen: Synthetic peptide of human HAS1

Swissprot: Q92839
Gene Accession: NP_001514

Calculated MW: 65 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-23145/sc-34020/sc-34021