HASP polyclonal antibody, anti-human, mouse, rat

Background:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis.,PTM:Autophosphorylated on both serine and threonine residues (By similarity). Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.,Contains 1 protein kinase domain.,tissue specificity:Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.,

Research Area: Epigenetics and nuclear signaling

Synonyms: Serine/threonine-protein kinase haspin , EC 2.7.11.1, Germ cell-specific gene 2 protein, H-haspin, Haploid germ cell-specific nuclear protein kinase

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year