HAX1 Polyclonal Antibody

Background:
The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
HAX1, HCLSBP1, HS1BP1, SCN3

Immunogen: Recombinant fusion protein of human HAX1 (NP_006109.2).

Swissprot: O00165
Gene ID: 10456

Calculated MW: 14 kDa/21 kDa/26 kDa/28 kDa/31 kDa/32 kDa
Observed MW: 36 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.