HBG1/HBG2 Polyclonal Antibody

Background:
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Research Area: Cardiovascular

Synonyms:
A gamma globin, G gamma globin, Gamma 1 globin, Gamma 2 globin, Gamma A hemoglobin, Gamma globin, Hb F Agamma, Hb F Ggamma, hbfagamma, hbfggamma, HBG 1, HBG 2, HBG1, HBG2, HBGA, HBGR, Hemoglobin gamma 1 chain , Hemoglobin gamma 2 chain , Hemoglobin gamma A, Hemoglobin gamma A chain , Hemoglobin gamma G, Hemoglobin gamma G chain , Hemoglobin gamma regulator of, Hemoglobin subunit gamma 1, Hemoglobin subunit gamma 2, HSGGL 1, HSGGL1, Methemoglobin, PRO 2979, PRO2979

Immunogen: Fusion protein of human HBG1/HBG2

Swissprot: P69891,P69892
Gene Accession: BC010914

Calculated MW: 16 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.6 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.