hCG-intact (clone HCGh25), anti-human

Source:
A BALB/c mouse was immunized with purified hCG.
Fusion partner: SP-2/0.

Specifications:
HCGh25 is very special because it reacts ONLY with intact-hCG and not with either free alpha- or free beta-chain of hCG. hCG is a glycoprotein composed of two non-identical, non-covalently linked polypeptide chains. The alpha subunit is identical among hCG, TSH, FSH and LH. While hCG is secreted in large quantities by normal trophoblasts, it is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. Besides trophoblastic tumors e.g. choriocarcinoma, large cell carcinoma, adenocarcinoma and squamous cell carcinoma of the lung are also positive in 90%, 60% and 20% of cases respectively. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

Species reactivity:
Positive: human.

Applications:
Pregnancy and oncology.
Frozen sections: +
Paraffin sections: Citrate

Positive control: JAR or TT Cells. Placenta.

References:
- McDonald EA et. al. Endocrinology 150:4358-65 (2009).