HCN2 Polyclonal Antibody

Background:
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.

Research Area: Cardiovascular, Neuroscience

Synonyms:
BCNG-2, BCNG2, Brain cyclic nucleotide gated channel 2, Brain cyclic nucleotide-gated channel 2, HAC1, Hcn2, HCN2, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Immunogen: Synthetic peptide of human HCN2

Swissprot: Q9UL51
Gene Accession: NP_001185

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-19708/sc-19710