HDAC1 Antibody (S421) Blocking Peptide
€363.00
In stock
SKU
AC-BP1101d
Background:
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Other Names:
Histone deacetylase 1, HD1, HDAC1, RPD3L1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1101d was selected from the S421 region of human HDAC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HDAC1 {ECO:0000303|PubMed:10846170, ECO:0000312|HGNC:HGNC:4852}
Gene ID: 3065
Primary Accession: Q13547
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Other Names:
Histone deacetylase 1, HD1, HDAC1, RPD3L1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1101d was selected from the S421 region of human HDAC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HDAC1 {ECO:0000303|PubMed:10846170, ECO:0000312|HGNC:HGNC:4852}
Gene ID: 3065
Primary Accession: Q13547
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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