HDAC1 Blocking Peptide(C-term)

Background:
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Other Names:
Histone deacetylase 1, HD1, HDAC1, RPD3L1

Target/Specificity:
The synthetic peptide sequence is selected from aa 436-450 of HUMAN HDAC1

Gene Name: HDAC1 {ECO:0000303|PubMed:10846170, ECO:0000312|HGNC:HGNC:4852}

Gene ID: 3065
Primary Accession: Q13547
Other Accession: Q4QQW4; O09106; Q32PJ8; NP_004955.2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.