HDAC1 (clone 2A1D3), anti-

Background:
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Research Area: Epigenetics and Nuclear Signaling

Synonyms: HD1, RPD3, KDAC1, GON-10, RPD3L1

Immunogen: Purified recombinant fragment of human HDAC1 (AA: 321-482) expressed in E. Coli.

Formulation: Purified antibody in PBS with 0.05% sodium azide

Storage:
4°C|-20°C for long term storage