HDAC1 monoclonal, anti-human
€0.00
In stock
SKU
AC-AM2204b
Catalog Number: AC-AM2204b
Size: 80 µl, 400 µl
Isotype: mouse IgM,κ
Clone Name: 1061CT1.3.1
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgM,κ
Clone Name: 1061CT1.3.1
Applications: WB
Datasheet
Request Information
Background:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
Other Names:
Histone deacetylase 1, HD1, HDAC1, RPD3L1
Target/Specificity:
Purified His-tagged HDAC1 protein was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: HDAC1 {ECO:0000303|PubMed:10846170, ECO:0000312|HGNC:HGNC:4852}
Gene ID: 3065
Primary Accession: Q13547
NCBI Accession: NP_004955.2
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
Other Names:
Histone deacetylase 1, HD1, HDAC1, RPD3L1
Target/Specificity:
Purified His-tagged HDAC1 protein was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: HDAC1 {ECO:0000303|PubMed:10846170, ECO:0000312|HGNC:HGNC:4852}
Gene ID: 3065
Primary Accession: Q13547
NCBI Accession: NP_004955.2
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
| Is Featured? | No |
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