HDAC11 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP1111a
Background:
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
Other Names:
Histone deacetylase 11, HD11, HDAC11
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1111a was selected from the N-term region of human HDAC11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HDAC11
Gene ID: 79885
Primary Accession: Q96DB2
Other Accession: NP_079103
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
Other Names:
Histone deacetylase 11, HD11, HDAC11
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1111a was selected from the N-term region of human HDAC11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HDAC11
Gene ID: 79885
Primary Accession: Q96DB2
Other Accession: NP_079103
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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