HDAC2/Histone Deacetylase 2 monoclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO13695
Catalog Number: AC-ABO13695
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IP
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IP
Datasheet
Request Information
Description: Anti-HDAC2/Histone Deacetylase 2 Rabbit Monoclonal Antibody . Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.
Protein Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A..
Other Names: Histone deacetylase 2, HD2, 3.5.1.98, Protein deacylase HDAC2, 3.5.1.-, HDAC2 {ECO:0000303|PubMed:10545197, ECO:0000312|HGNC:HGNC:4853}
Clone Name(s):
Clone: HED-8
Subcellular Localization: Nucleus. Cytoplasm.
Tissue Specificity: Widely expressed; lower levels in brain and lung.
Gene ID: 3066
Immunogen: A synthesized peptide derived from human HDAC2
Calculated MW: 55364
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A..
Other Names: Histone deacetylase 2, HD2, 3.5.1.98, Protein deacylase HDAC2, 3.5.1.-, HDAC2 {ECO:0000303|PubMed:10545197, ECO:0000312|HGNC:HGNC:4853}
Clone Name(s):
Clone: HED-8
Subcellular Localization: Nucleus. Cytoplasm.
Tissue Specificity: Widely expressed; lower levels in brain and lung.
Gene ID: 3066
Immunogen: A synthesized peptide derived from human HDAC2
Calculated MW: 55364
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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