HDAC3 polyclonal, anti-human, mouse, rat

Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Synonyms: HD3, RPD3, RPD3-2

Cellular Location: Cytoplasm Nucleus cytosol

Immunogen:
Recombinant protein of human HDAC3

Gene Symbol: HDAC3

Gene ID: 8841

Swiss prot: O15379

Calculated MW: 49kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-100, IF 1:50-200, IP 1:50-200, ChIP 1:20-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.