HDAC4 (clone 7B2), anti-human

Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Research Area: Epigenetics and Nuclear Signaling

Synonyms: HD4, HDACA, HA6116, HDAC-A, KIAA0288, HDAC4

Immunogen: Purified recombinant fragment of human HDAC4 expressed in E. Coli.

Formulation: Purified antibody in PBS containing 0.05% sodium azide.

Storage:
4°C|-20°C for long term storage