HDAC4 (N-term) polyclonal, anti-human, mouse, rat

Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Synonyms: HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A

Cellular Location: Cytoplasm Nucleus

Immunogen:
A synthetic peptide of human HDAC4

Gene Symbol: HDAC4

Gene ID: 9759

Swiss prot: P56524

Calculated MW: 119 kDa/106 kDa

Recommended dilution:
IHC 1:25-100

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.