HDAC5 (phospho-S498) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4086
Background:
HDAC5 is a member of the class II mammalian histone deacetylase family, which is structurally related to yeast HDA1. Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence.Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.
Alternative Name:
Histone deacetylase 5, Short name=HD5, Antigen NY-CO-9, HDAC-5, KIAA0600
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-HDAC5 (S498) polyclonal antibody detects endogenous levels of HDAC5 protein only when phosphorylated at Ser498.
Immunogen:
Synthetic phosphopeptide derived from human HDAC5 around the phosphorylation site of Serine 498.
MW: ~ 121 kDa
Swis Prot.: Q9UQL6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
HDAC5 is a member of the class II mammalian histone deacetylase family, which is structurally related to yeast HDA1. Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence.Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.
Alternative Name:
Histone deacetylase 5, Short name=HD5, Antigen NY-CO-9, HDAC-5, KIAA0600
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-HDAC5 (S498) polyclonal antibody detects endogenous levels of HDAC5 protein only when phosphorylated at Ser498.
Immunogen:
Synthetic phosphopeptide derived from human HDAC5 around the phosphorylation site of Serine 498.
MW: ~ 121 kDa
Swis Prot.: Q9UQL6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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