HDAC5 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Histone deacetylase 5, also called HDAC5 or KIAA0600, is an enzyme that in humans is encodes by the HDAC5 gene. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. This gene is mapped to 17q21.31. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2(MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is though to be associated with colon cancer.

Description:
Rabbit IgG polyclonal antibody for Histone deacetylase 5 (HDAC5) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Antigen NY CO 9 antibody, Antigen NY-CO-9 antibody, FLJ90614 antibody, HD 5 antibody, HD5 antibody, HDAC 5 antibody, HDAC5 antibody, HDAC5_HUMAN antibody, Histone deacetylase 5 antibody, KIAA0600 antibody, NY CO 9 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human HDAC5(626-644aa YKKLFSDAQPLQPLQVYQA), different from the related rat and mouse sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.