HDAC6 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP1106a
Catalog Number: AC-AP1106a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5653
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5653
Applications: IHC-P, WB
Datasheet
Request Information
Background:
HDAC6 (histone deacetylase 6) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays a central role in microtubule-dependent cell motility via deacetylation of tubulin, and has been shown to interact with HDAC11, SIRT2, and F-actin. HDAC6 is ubiquitinated, but its polyubiquitination however does not lead to degradation. HDAC is also a potential target of sumoylation.
Other Names:
Histone deacetylase 6, HD6, HDAC6, KIAA0901
Target/Specificity:
This HDAC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1182-1215 amino acids from the C-terminal region of human HDAC6.
Antigen Region:
1182-1215
Antigen Type: Synthetic Peptide
Gene Name: HDAC6 {ECO:0000303|PubMed:10220385, ECO:0000312|HGNC:HGNC:14064}
Gene ID: 10013
Primary Accession: Q9UBN7
NCBI Accession: NP_006035.2
Other Accession: NP_006035
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
HDAC6 (histone deacetylase 6) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays a central role in microtubule-dependent cell motility via deacetylation of tubulin, and has been shown to interact with HDAC11, SIRT2, and F-actin. HDAC6 is ubiquitinated, but its polyubiquitination however does not lead to degradation. HDAC is also a potential target of sumoylation.
Other Names:
Histone deacetylase 6, HD6, HDAC6, KIAA0901
Target/Specificity:
This HDAC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1182-1215 amino acids from the C-terminal region of human HDAC6.
Antigen Region:
1182-1215
Antigen Type: Synthetic Peptide
Gene Name: HDAC6 {ECO:0000303|PubMed:10220385, ECO:0000312|HGNC:HGNC:14064}
Gene ID: 10013
Primary Accession: Q9UBN7
NCBI Accession: NP_006035.2
Other Accession: NP_006035
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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