HDAC8/Histone Deacetylase 8 monoclonal, anti-human

Description: Anti-HDAC8/Histone Deacetylase 8 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human.

Protein Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility..

Other Names: Histone deacetylase 8, HD8, 3.5.1.98, Protein deacetylase HDAC8, 3.5.1.-, Protein decrotonylase HDAC8, 3.5.1.-, HDAC8 {ECO:0000303|PubMed:10926844, ECO:0000312|HGNC:HGNC:13315}

Clone Name(s):
Clone: HIO-8

Subcellular Localization: Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

Tissue Specificity: Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney..

Gene ID: 55869

Immunogen: A synthesized peptide derived from human HDAC8

Calculated MW: 41758

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.