HDGF rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016],domain:The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured.,function:Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.,PTM:Sumoylated by SUMO1. Sumoylation prevents binding to chromatin.,similarity:Belongs to the HDGF family.,similarity:Contains 1 PWWP domain.,subunit:Monomer, and domain-swapped homodimer.,tissue specificity:Ubiquitous.,

Synonyms: Hepatoma-derived growth factor (HDGF, High mobility group protein 1-like 2, HMG-1L2)

Gene Name: HDGF HMG1L2

Gene ID: 3068

SwissProt ID: P51858

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.