Heat shock protein 60, HSP60 (clone H6-2), anti-human, mouse, rat
€0.00
In stock
SKU
BMA1023
Catalog Number: BMA1023
Size: 100 μg
Isotype: Mouse IgG1
Reactivity: human, mouse,rat
Application(s): WB, IHC-P, ICC
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Size: 100 μg
Isotype: Mouse IgG1
Reactivity: human, mouse,rat
Application(s): WB, IHC-P, ICC
Request Information
Background:
Heat shock protein 60 (HSP60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins. Hsp60 belongs to a class of structurally related chaperonins found in organelles of endosymbiotic origin and in the bacterial cytosol.1Members of the chaperonin class include the Escherichia coli, groEL protein and the Rubisco subunit-binding protein of chloroplasts.2In both prokaryotic and eukaryotic systems, synthesis of these proteins is induced in response to stresses, such as heat shock.3Under normal physiological conditions, HSP60 is a 60 KD oligomer composed of monomers that form a complex arranged as two stacked heptameric rings.1HSP60 may be a very useful marker for patients with superficial bladder carcinoma and may be used for predicting disease progression. And low HSP60 expression levels may be usable as a prognostic marker to identify patients for whom local treatment would be insufficient.4HSP60 also linked to diabetes, cancer and certain types of immunological disorders.
Immunogen:
A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of HSP60.
Recommended Application:
Western Blot, WB(1:1000); Immunohistochemistry, IHC-P (1:100); Immunocytochemistry, ICC (1:100)
Product Form: Liquid
Purification: Protein A purified
Storage Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.
Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.
Heat shock protein 60 (HSP60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins. Hsp60 belongs to a class of structurally related chaperonins found in organelles of endosymbiotic origin and in the bacterial cytosol.1Members of the chaperonin class include the Escherichia coli, groEL protein and the Rubisco subunit-binding protein of chloroplasts.2In both prokaryotic and eukaryotic systems, synthesis of these proteins is induced in response to stresses, such as heat shock.3Under normal physiological conditions, HSP60 is a 60 KD oligomer composed of monomers that form a complex arranged as two stacked heptameric rings.1HSP60 may be a very useful marker for patients with superficial bladder carcinoma and may be used for predicting disease progression. And low HSP60 expression levels may be usable as a prognostic marker to identify patients for whom local treatment would be insufficient.4HSP60 also linked to diabetes, cancer and certain types of immunological disorders.
Immunogen:
A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of HSP60.
Recommended Application:
Western Blot, WB(1:1000); Immunohistochemistry, IHC-P (1:100); Immunocytochemistry, ICC (1:100)
Product Form: Liquid
Purification: Protein A purified
Storage Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.
Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.
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