Heparan Sulphate Proteoglycan (clone A7L6), anti-human, mouse, rat, bovine
€564.00
In stock
SKU
ARP-21-5087
Catalog Number: 21-5087
Size: 100 µg
Isotype: Rat IgG2a
Size: 100 µg
Isotype: Rat IgG2a
Background:
Proteoglycans are macromolecules consisting of a variety of core proteins with covalently attached one or several polysaccharide chains of the glycosaminoglycan type (heparan sulphate, heparin, chondroitin sulphate, dermatan sulphate or keRatan sulphate). At least two forms of basement membrane heparan sulphate proteoglycan (HSPG) have been identified. One with a large core protein (> 400 kD) and one with a small core protein (30 kD). The large HSPG is probably the most abundant basement membrane proteoglycan. It is loCated predominantly in the lamina lucida, where it forms clustered aggregates and interacts with other basement membrane components to form the matrix. In addition, it also plays a critical role in attachment of cells to the basal membrane via integrin receptors.
Clone: A7L6
Isotype: Rat IgG2a
Source: A7L6 is a Rat monoclonal IgG2a antibody derived by fusion of X63 Ag8.653 Mouse myeloma cells with spleen cells from a Fisher Rat immunized with high molecular mass material derived from the Engelbreth-Holm-Swarm (EHS) tumor matrix containing laminin, entactin and HSPG.
Reactivity: bovine, human, mouse, rat
Specificity: A7L6 recognizes domain IV of the core protein of the large heparan sulphate proteoglycan or perlecan. The reactivity is independent of the galactosaminoglycan moieties. Therefore, the epitope is not sensitive to heparitinase treatment.
Form: Each vial contains 100ul of monoclonal purified antibody in PBS containing 0.09% sodium azide.
Applications: Immunocytochemistry, Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
Proteoglycans are macromolecules consisting of a variety of core proteins with covalently attached one or several polysaccharide chains of the glycosaminoglycan type (heparan sulphate, heparin, chondroitin sulphate, dermatan sulphate or keRatan sulphate). At least two forms of basement membrane heparan sulphate proteoglycan (HSPG) have been identified. One with a large core protein (> 400 kD) and one with a small core protein (30 kD). The large HSPG is probably the most abundant basement membrane proteoglycan. It is loCated predominantly in the lamina lucida, where it forms clustered aggregates and interacts with other basement membrane components to form the matrix. In addition, it also plays a critical role in attachment of cells to the basal membrane via integrin receptors.
Clone: A7L6
Isotype: Rat IgG2a
Source: A7L6 is a Rat monoclonal IgG2a antibody derived by fusion of X63 Ag8.653 Mouse myeloma cells with spleen cells from a Fisher Rat immunized with high molecular mass material derived from the Engelbreth-Holm-Swarm (EHS) tumor matrix containing laminin, entactin and HSPG.
Reactivity: bovine, human, mouse, rat
Specificity: A7L6 recognizes domain IV of the core protein of the large heparan sulphate proteoglycan or perlecan. The reactivity is independent of the galactosaminoglycan moieties. Therefore, the epitope is not sensitive to heparitinase treatment.
Form: Each vial contains 100ul of monoclonal purified antibody in PBS containing 0.09% sodium azide.
Applications: Immunocytochemistry, Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
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