Hepatitis C Virus (HCV) NS5B (clone 5B-3B1), anti-virus
€264.00
In stock
SKU
ARP-23-B0002
Catalog Number: 23-B0002
Size: 25 µg
Isotype: Mouse IgG2b
Size: 25 µg
Isotype: Mouse IgG2b
Decription:
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Synonyms: Nonstructural Protein 5B
Clone: 5B-3B1
Isotype: Mouse IgG2b
Immunogen: Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (genotype 1a).
Reactivity: HCV
Specificity: Recognizes HCV NS5B (epitope mapped to NS5B aa 372-382). It recognizes genotype 1 a and also 1b (albeit with lower affinity). It does not recognize genotype 2a.
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Western Blot: (1:1'000)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Synonyms: Nonstructural Protein 5B
Clone: 5B-3B1
Isotype: Mouse IgG2b
Immunogen: Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (genotype 1a).
Reactivity: HCV
Specificity: Recognizes HCV NS5B (epitope mapped to NS5B aa 372-382). It recognizes genotype 1 a and also 1b (albeit with lower affinity). It does not recognize genotype 2a.
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Western Blot: (1:1'000)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
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