Hepsin polyclonal, anti-human, rat

Quantity: 100 µg

Background:
HPN(Hepsin), also known as TMPRSS1, is an enzyme that in humans is encoded by the HPN gene. Tsuji et al.(1991) mapped the hepsin gene to 19q11-q13.2. Using cDNA microarrays, Dhanasekaran et al.(2001) examined gene expression profiles of more than 50 normal and neoplastic prostate specimens and 3 common prostate cancer cell lines. Signature expression profiles of normal adjacent prostate, benign prostatic hypertrophy, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. In 3 different human cell lines, Guipponi et al.(2008) found that TMPRSS1 was stably anchored in the endoplasmic reticulum.

Description:
Rabbit IgG polyclonal antibody for Serine protease hepsin (HPN) detection. Tested with WB in Human, Rat.

Synonyms:
EC 3.4.21. antibody, HEPS antibody, HEPS_HUMAN antibody, Hepsin antibody, HPN antibody, Serine protease hepsin antibody, Serine protease hepsin catalytic chain antibody, Serine protease hepsin non catalytic chain antibody, TMPRSS 1 antibody, TMPRSS1 antibody, Transmembrane protease serine 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Hepsin(392-410aa KVSDFREWIFQAIKTHSEA), different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human Hepsin(392-410aa KVSDFREWIFQAIKTHSEA), different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.