HERPUD1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP17228a
Background:
The accumulation of unfolded proteins in the endoplasmicreticulum (ER) triggers the ER stress response. This responseincludes the inhibition of translation to prevent furtheraccumulation of unfolded proteins, the increased expression ofproteins involved in polypeptide folding, known as the unfoldedprotein response (UPR), and the destruction of misfolded proteinsby the ER-associated protein degradation (ERAD) system. This genemay play a role in both UPR and ERAD. Its expression is induced byUPR and it has an ER stress response element in its promoter regionwhile the encoded protein has an N-terminal ubiquitin-like domainwhich may interact with the ERAD system. This protein has beenshown to interact with presenilin proteins and to increase thelevel of amyloid-beta protein following its overexpression.Alternative splicing of this gene produces multiple transcriptvariants, some encoding different isoforms. The full-length natureof all transcript variants has not been determined. [provided byRefSeq].
Other Names:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, Methyl methanesulfonate (MMF)-inducible fragment protein 1, HERPUD1, HERP, KIAA0025, MIF1
Gene Name: HERPUD1
Gene ID: 9709
Primary Accession: Q15011
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The accumulation of unfolded proteins in the endoplasmicreticulum (ER) triggers the ER stress response. This responseincludes the inhibition of translation to prevent furtheraccumulation of unfolded proteins, the increased expression ofproteins involved in polypeptide folding, known as the unfoldedprotein response (UPR), and the destruction of misfolded proteinsby the ER-associated protein degradation (ERAD) system. This genemay play a role in both UPR and ERAD. Its expression is induced byUPR and it has an ER stress response element in its promoter regionwhile the encoded protein has an N-terminal ubiquitin-like domainwhich may interact with the ERAD system. This protein has beenshown to interact with presenilin proteins and to increase thelevel of amyloid-beta protein following its overexpression.Alternative splicing of this gene produces multiple transcriptvariants, some encoding different isoforms. The full-length natureof all transcript variants has not been determined. [provided byRefSeq].
Other Names:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, Methyl methanesulfonate (MMF)-inducible fragment protein 1, HERPUD1, HERP, KIAA0025, MIF1
Gene Name: HERPUD1
Gene ID: 9709
Primary Accession: Q15011
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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