HES-2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60286
Background:
The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
Alternative Name:
Transcription factor HES-2, Class B basic helix-loop-helix protein 40, bHLHb40, Hairy and enhancer of split 2, HES2, BHLHB40
Application Dilution: WB: 1:500~1:1000
Specificity: HES-2 polyclonal antibody detects endogenous levels of HES-2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human HES-2.
MW: ~ 18 kDa
Swis Prot.: Q9Y543
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
Alternative Name:
Transcription factor HES-2, Class B basic helix-loop-helix protein 40, bHLHb40, Hairy and enhancer of split 2, HES2, BHLHB40
Application Dilution: WB: 1:500~1:1000
Specificity: HES-2 polyclonal antibody detects endogenous levels of HES-2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human HES-2.
MW: ~ 18 kDa
Swis Prot.: Q9Y543
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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