Hes1 polyclonal, anti-rat, human, mouse

Quantity: 100 µg

Background:
Transcription factor HES-1, also called HRY or HES-1 is a protein that is encoded by the HES1 gene. This gene belongs to a family of basic helix-loop-helix(bHLH) proteins that are essential for neurogenesis, myogenesis, hematopoiesis, and sex determination. This gene is mapped to 3q29. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. This gene may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. It may play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

Description:
Rabbit IgG polyclonal antibody for Transcription factor HES-1 (HES1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
bHLHb39 antibody, C-HAIRY1 antibody, c-hairy1A antibody, Class B basic helix-loop-helix protein 39 antibody, FLJ20408 antibody, Hairy and enhancer of split 1(Drosophila) antibody, Hairy and enhancer of split 1 antibody, Hairy Enhancer of Split 1 antibody, Hairy homolog(Drosophila) antibody, Hairy Homolog antibody, Hairy like antibody, Hairy, Drosophila, homolog of antibody, Hairy-like protein antibody, Hairy/enhancer of split, Drosophila, homolog of, 1 antibody, HAIRY1 antibody, HES-1 antibody, hes1 antibody, Hes1 hairy and enhancer of split 1(Drosophila) antibody, HES1_HUMAN antibody, HHL antibody, HL antibody, HRY antibody, MGC129109 antibody, OTTHUMP00000209031 antibody, RHL antibody, Transcription factor HES 1 antibody, Transcription factor HES-1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human Hes1(142-155aa HLANCMTQINAMTY), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence in the middle region of human Hes1(142-155aa HLANCMTQINAMTY), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat.
Predicted to work with: human, mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.