HES1 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP21002c
Catalog Number: AC-AP21002c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB51476
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB51476
Applications: WB
Datasheet
Request Information
Background:
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Other Names:
Transcription factor HES-1, Class B basic helix-loop-helix protein 39, bHLHb39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, hHL, HES1, BHLHB39, HL, HRY
Target/Specificity:
This HES1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 259-293 amino acids from the C-terminal region of human HES1.
Gene Name: HES1
Gene ID: 3280
Primary Accession: Q14469
Other Accession: Q3ZBG4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Other Names:
Transcription factor HES-1, Class B basic helix-loop-helix protein 39, bHLHb39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, hHL, HES1, BHLHB39, HL, HRY
Target/Specificity:
This HES1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 259-293 amino acids from the C-terminal region of human HES1.
Gene Name: HES1
Gene ID: 3280
Primary Accession: Q14469
Other Accession: Q3ZBG4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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