HFE2 polyclonal, anti-human, rat
€388.00
In stock
SKU
BS7548
Background:
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Alternative Name:
2310035L15Rik, 5230400G09Rik, AI414844, AI789733, DL M, Haemojuvelin, HEMOCHROMATOSIS, HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN, HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE, HEMOCHROMATOSIS JUVENILE, Hemochromatosis type 2 (juvenile), Hemochromatosis type 2, Hemochromatosis type 2 protein, Hemochromatosis type 2 protein homolog, HEMOCHROMATOSIS, TYPE 2A, HEMOCHROMATOSIS, TYPE 2B, Hemojuvelin, HFE 2, Hfe2, HFE2A, HJV, JH, Juvenile, MGC23953, OTTHUMP00000059680, Repulsive guidance molecule c, RGM C, RGM domain family member C, RGMC,
Application Dilution: WB: 1:500 - 1:2000
Specificity: HFE2 polyclonal antibody detects endogenous levels of HFE2 protein.
Immunogen:
Recombinant full length Human HFE2.
MW: ~45 kDa
Swis Prot.: Q6ZVN8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Alternative Name:
2310035L15Rik, 5230400G09Rik, AI414844, AI789733, DL M, Haemojuvelin, HEMOCHROMATOSIS, HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN, HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE, HEMOCHROMATOSIS JUVENILE, Hemochromatosis type 2 (juvenile), Hemochromatosis type 2, Hemochromatosis type 2 protein, Hemochromatosis type 2 protein homolog, HEMOCHROMATOSIS, TYPE 2A, HEMOCHROMATOSIS, TYPE 2B, Hemojuvelin, HFE 2, Hfe2, HFE2A, HJV, JH, Juvenile, MGC23953, OTTHUMP00000059680, Repulsive guidance molecule c, RGM C, RGM domain family member C, RGMC,
Application Dilution: WB: 1:500 - 1:2000
Specificity: HFE2 polyclonal antibody detects endogenous levels of HFE2 protein.
Immunogen:
Recombinant full length Human HFE2.
MW: ~45 kDa
Swis Prot.: Q6ZVN8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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