HFE2 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP9699b
Catalog Number: AC-AP9699b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22186
Applications: FC, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22186
Applications: FC, WB
Datasheet
Request Information
Background:
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Other Names:
Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC
Target/Specificity:
This HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-338 amino acids from the C-terminal region of human HFE2.
Antigen Region:
308-338
Antigen Type: Synthetic Peptide
Gene Name: HJV (HGNC:4887)
Gene ID: 148738
Primary Accession: Q6ZVN8
NCBI Accession: NP_660320.3;NP_973733.1;NP_998817.1;NP_998818.1
Other Accession: Q8N7M5; Q7TQ32
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Other Names:
Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC
Target/Specificity:
This HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-338 amino acids from the C-terminal region of human HFE2.
Antigen Region:
308-338
Antigen Type: Synthetic Peptide
Gene Name: HJV (HGNC:4887)
Gene ID: 148738
Primary Accession: Q6ZVN8
NCBI Accession: NP_660320.3;NP_973733.1;NP_998817.1;NP_998818.1
Other Accession: Q8N7M5; Q7TQ32
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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